Talk:COVID-19

Viral complex assembly and long term effects of Covid

The Dutch language version of the page includes a reference to a recently published PNAS article which talks about virus fragments assembling into complexes that may help to explain some of the effects of Long Covid infections. I think that this would be a good inclusion into the Long-term effects section of this article. VoluntasDei (talk) 03:50, 11 March 2024 (UTC)

That would be

• Zhang Y, Bharathi V, Dokoshi T, de Anda J, Ursery LT, et al. (February 2024). "Viral afterlife: SARS-CoV-2 as a reservoir of immunomimetic peptides that reassemble into proinflammatory supramolecular complexes". Proc Natl Acad Sci U S A. 121 (6): e2300644120. doi:10.1073/pnas.2300644120. PMC 10861912. PMID 38306481.

which is primary research. If it gets picked up by WP:MEDRS sources, material on this would then be usable here. Bon courage (talk) 03:54, 11 March 2024 (UTC)

Extended-confirmed-protected edit request on 8 May 2024

§ Other species:

As expected, monkeys and great ape species such as orangutans can also be infected with the COVID‑19 virus.

Providing reliable sources

As written, this either excludes lesser apes or else includes great apes twice over (cf the opening paragraph of monkey), which is odd either way. What the ref actually says is

The findings on ferrets, orangutans, and monkeys showed a higher affinity of ACE2 with the RBD domain of SARS-CoV-2 S protein [1].

That citation in turn says the following:

2019-nCoV RBD likely recognizes ACE2 from pigs, ferrets, cats, orangutans, monkeys, and humans with similar efficiencies, because these ACE2 molecules are identical or similar in the critical virus-binding residues.

[...]

Pigs, ferrets, cats, and nonhuman primates contain largely favorable 2019-nCoV-contacting residues in their ACE2 and hence may serve as animal models or intermediate hosts for 2019-nCoV.

However, the previous paragraph of § Other species disagrees about pigs in particular:

The virus does not appear to be able to infect pigs, ducks, or chickens at all.

Again ref plus secondary citation:

However, Shi et al. reported that ferrets and cats were highly susceptible to SARS-CoV-2, while dogs had a low susceptibility and livestock including pigs, chickens, and ducks were not susceptible to the virus, under experimental conditions [2].

->

Dogs appeared not to support viral replication well and had low susceptibility to the virus, and pigs, chickens, and ducks were not susceptible to SARS-CoV-2.

[...]

We found that SARS-CoV-2 replicates poorly in dogs, pigs, chickens, and ducks, but ferrets and cats are permissive to infection.

[...]

We also investigated the susceptibility of pigs, chickens, and ducks to SARS-CoV-2 by using the same strategy as that used to assess dogs. However, viral RNA was not detected in any swabs collected from these virus-inoculated animals or from naïve contact animals (Table 1). In addition, all of these animals were seronegative for SARS-CoV-2 when tested by ELISA with sera collected on day 14 p.i. (Table 1). These results indicate that pigs, chickens, and ducks are not susceptible to SARS-CoV-2.

In summary, we found that ferrets and cats are highly susceptible to SARS-CoV-2; dogs have low susceptibility; and pigs, chickens, and ducks are not susceptible to the virus.

Generally, translating some of the refs' protein-level results into organism-level claims like "can be infected" seems suspect.

Mentioning the specific changes in a "change X to Y" format

Maybe put an OR tag on the section?

Specifically, suggest changing

As expected, monkeys and great ape species such as orangutans can also be infected with the COVID‑19 virus.

to

Orangutans and other primates may also be vulnerable to COVID‑19 infection.

at minimum.

- 2A02:560:59A1:EF00:BD31:F556:FA77:6F84 (talk) 16:13, 8 May 2024 (UTC)

 Not done: it's not clear what changes you want to be made. Please mention the specific changes in a "change X to Y" format and provide a reliable source if appropriate. Shadow311 (talk) 15:23, 8 May 2024 (UTC)

Added subheadings to the OP to clarify where it's suggesting changes and where it's discussing sources. - 2A02:560:59A1:EF00:BD31:F556:FA77:6F84 (talk) 16:13, 8 May 2024 (UTC)