User:Logophile59/sandbox/Angela DePace
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Professor Angela DePace Ph.D. | |
|---|---|
| Citizenship | USA |
| Education | University of California, San Francisco |
| Spouse | Edward Pym |
| Scientific career | |
| Institutions | Harvard Medical School |
| Academic advisors | Jonathan Weissman Michael Eisen |
Angela DePace is an American biophysicist. During her Ph.D. work, she identified the prion domain in yeast prions,[1] leading to insights into how a single protein can generate multiple infectious prion strains.[2][3][4] She is an Associate Professor at Harvard Medical School, where her laboratory investigates the mechanism and evolution of the regulation of gene expression in animals.
Education[edit]
Dr. DePace received her bachelor’s degree in Molecular Biophysics and Biochemistry from Yale University in 1996, and a Ph.D. in Biochemistry from the University of California, San Francisco in 2002. She performed her graduate work in the laboratory of Jonathan Weissman. She was a Helen Hay Whitney Foundation postdoctoral fellow at the University of California, Berkeley in the laboratory of Michael Eisen.
Career[edit]
DePace's graduate work on prions[2][3] is credited with solving the problem of what prevents prions that affect one species from infecting another species, and providing insight into how this transmission barrier fails, as happens in mad cow disease.[4][5]
She joined the faculty at Harvard Medical School in 2008. Her laboratory investigates the mechanism and evolution of gene expression in animals, using Drosophila embryos as a model system. With Jeremy Gunawardena, she has argued that the effects of energy expenditure during gene regulation may be underestimated.[6][7]
DePace is an advocate for broadening the training of biomedical researchers to prepare students and postdocs for careers outside academic research. With several of her trainees, she wrote an influential[8][9] piece on the usefulness of individual development plans as a tool for career planning.[10] She teaches communication as a core discipline essential for both academic science and other careers, and co-authored a book on science communication through graphics, "Visual Strategies: A Practical Guide to Graphics for Scientists and Engineers", with Felice Frankel.[11][12] She founded the Science Citizenship Initiative at Harvard, which aims to train scientists for socially responsive and responsible work in the communities they serve,[13] and as of 2019 serves as its Faculty Director.[14]
As of 2019[update], she is the Chair of the Public Affairs Committee of the Society for Developmental Biology.[15]
Awards[edit]
- 1995: William L. Learned Scholarship, Yale University
- 1997: HHMI predoctoral fellowship[16]
- 2004: Helen Hay Whitney Foundation Fellowship
- 2015: NSF Career Award[17]
References[edit]
- ^ DePace, Angela H; Santoso, Alex; Hillner, Paul; Weissman, Jonathan S. (1998-06-26). "A Critical Role for Amino-Terminal Glutamine/Asparagine Repeats in the Formation and Propagation of a Yeast Prion". Cell. 93 (7): 1241–1252. doi:10.1016/S0092-8674(00)81467-1. ISSN 0092-8674. PMID 9657156.
- ^ a b DePace, Angela H.; Weissman, Jonathan S. (2002). "Origins and kinetic consequences of diversity in Sup35 yeast prion fibers". Nature Structural Biology. 9 (5): 389–396. doi:10.1038/nsb786. ISSN 1072-8368. PMID 11938354.
- ^ a b Chien, Peter; DePace, Angela H.; Collins, Sean R.; Weissman, Jonathan (2003). "Generation of prion transmission barriers by mutational control of amyloid conformations". Nature. 424 (6951): 948–951. doi:10.1038/nature01894. ISSN 1476-4687.
- ^ a b Sherman, Michael Y. (2004-04-13). "Yeast Prions: Protein Aggregation Is Not Enough". PLOS Biology. 2 (4): e125. doi:10.1371/journal.pbio.0020125. ISSN 1545-7885. PMC 387287. PMID 15094820.
{{cite journal}}: CS1 maint: PMC format (link) CS1 maint: unflagged free DOI (link) - ^ "Tipping the Balance of Prion Infectivity". HHMI.org. Retrieved 2019-08-03.
- ^ Estrada, Javier; Wong, Felix; DePace, Angela; Gunawardena, Jeremy (2016-06-30). "Information Integration and Energy Expenditure in Gene Regulation". Cell. 166 (1): 234–244. doi:10.1016/j.cell.2016.06.012. ISSN 1097-4172. PMC 4930556. PMID 27368104.
- ^ Park, Jeehae; Estrada, Javier; Johnson, Gemma; Vincent, Ben J.; Ricci-Tam, Chiara; Bragdon, Meghan Dj; Shulgina, Yekaterina; Cha, Anna; Wunderlich, Zeba; Gunawardena, Jeremy; DePace, Angela H. (2019-06-21). "Dissecting the sharp response of a canonical developmental enhancer reveals multiple sources of cooperativity". eLife. 8. doi:10.7554/eLife.41266. ISSN 2050-084X. PMC 6588347. PMID 31223115.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Gearing, Mary. "IDP and your PI: A Roadmap for Career Planning and Personal Development". blog.addgene.org. Retrieved 2019-05-30.
- ^ Montgomery, Beronda L. (2017-04-01). "Mapping a Mentoring Roadmap and Developing a Supportive Network for Strategic Career Advancement". SAGE Open. 7 (2): 2158244017710288. doi:10.1177/2158244017710288. ISSN 2158-2440.
- ^ Vincent, Ben J.; Scholes, Clarissa; Staller, Max V.; Wunderlich, Zeba; Estrada, Javier; Park, Jeehae; Bragdon, Meghan D.J.; Lopez Rivera, Francheska, Biette, Kelly M.; DePace, Angela H. (2015). "Yearly Planning Meetings: Individualized Development Plans Aren't Just More Paperwork". Molecular Cell. 58 (5): 718–721. doi:10.1016/j.molcel.2015.04.025.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Frankel, Felice; DePace, Angela H. (2012). Visual strategies : a practical guide to graphics for scientists & engineers. New Haven [Conn.]: Yale University Press. ISBN 9780300183603. OCLC 853455868.
- ^ Dean, Cornelia (2012-09-03). "'Visual Strategies' Transforms Data Into Art That Speaks". The New York Times. ISSN 0362-4331. Retrieved 2019-08-03.
- ^ Rosenberg, John S. (2018-10-05). "Academic Harvard: The Inaugural Symposiums". Harvard Magazine. Retrieved 2019-08-03.
- ^ "Angela DePace". ethics.harvard.edu. Retrieved 2019-08-03.
- ^ "Society for Developmental Biology | Public Affairs Committee". www.sdbonline.org. Retrieved 2019-05-28.
- ^ "Howard Hughes Medical Institute Awards 166 Fellowships for Graduate Education, Medical Student Research Training". HHMI.org. Retrieved 2019-08-03.
- ^ "NSF Award Search: Award#1452557 - CAREER: Developmental Network Architecture Underlies Patterning Precision and Robustness". www.nsf.gov. Retrieved 2019-05-30.