Draft:Paola Marignani

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Paola A. Marignani
NationalityCanadian
Alma materUniversity of Windsor (H BSc)
University of Western Ontario (MSc)
McMaster University (PhD)
Harvard (Postdoctoral Fellow)
Ivey School of Business (EMBA)
Scientific career
FieldsMolecular Biology, Precision Medicine, Single-cell transcriptomics
InstitutionsDalhousie University
Websitehttps://marignanilab.com/

Paola A. Marignani is a scientist and Full Professor at Dalhousie University in the Faculty of Medicine, Department of Biochemistry and Molecular Biology.[1] She is best known for her research on the tumor suppressor kinase LKB1,[2] and its role in regulating the chromatin remodeling protein SMARCA4 and modeling metabolic processes in breast and lung cancers. [3][4][5]

Biography[edit]

Marignani completed her Hon BSc in Biology from the University of Windsor, followed by an MSc in Neurobiology from the University of Western Ontario.[1] She earned her PhD in Cell Biology from McMaster University. Her postdoctoral training took place at Harvard Medical School in the Division of Signal Transduction followed by the Lunenfeld-Tanenbaum Research Institute and the Ontario Cancer Institute in Toronto, Ontario. She also holds an Executive MBA from the Ivey School of Business at Western University, and a Certificate from MIT Sloan School of Management in Artificial Intelligence in Health Care.[6]

Scientific Career[edit]

The primary focus of Marignani’s research program is tumor suppressors.[7] Marignani combines technologies such as single-cell transcriptomics and machine learning[8] to interrogate disease processes within the framework of precision medicine discovery pipelines.[9][6][10][11] 

Marignani’s early research focused on understanding the molecular changes to signaling molecules resulting from polyunsaturated fatty acid incorporation into lipid membranes. She discovered that the integration of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) into lipid membranes altered diacylglycerol profiles in murine macrophages, which could lead to downstream changes in signaling events.[12]

Marignani is involved in promoting diversity and inclusion in STEM fields. She is the Founder of Canadian Women in STEM, an organization aimed at building a national strategy for equity, diversity, and inclusion in Canada, and provides an accessible network that enables ease of communication among women in STEM.[8]

Selected Publications[edit]

Scholia has an author profile for Paola Marignani.

References[edit]

  1. ^ a b "Marignani, P. A." Dalhousie University. Retrieved 2024-05-12.
  2. ^ Andrade-Vieira, Rafaela; Goguen, Donna; Bentley, Heidi A.; Bowen, Chris V.; Marignani, Paola A. (2014-12-30). "Pre-clinical study of drug combinations that reduce breast cancer burden due to aberrant mTOR and metabolism promoted by LKB1 loss". Oncotarget. 5 (24): 12738–12752. doi:10.18632/oncotarget.2818. ISSN 1949-2553. PMC 4350354. PMID 25436981.
  3. ^ Marignani, Paola A.; Kanai, Fumihiko; Carpenter, Christopher L. (2001-08-31). "LKB1 Associates with Brg1 and Is Necessary for Brg1-induced Growth Arrest". Journal of Biological Chemistry. 276 (35): 32415–32418. doi:10.1074/jbc.C100207200. PMID 11445556.
  4. ^ "Nova Scotia breast cancer researcher receives $250K grant". Atlantic. 2022-07-18. Retrieved 2024-05-12.
  5. ^ International, Radio Canada (2014-12-15). "Exciting Canadian advance against breast cancer". RCI | English. Retrieved 2024-05-13.
  6. ^ a b "$250,000 Grant to Dr. Paola Marignani to identify HER2+ markers". Breast Cancer Canada. 2022-06-15. Retrieved 2024-05-12.
  7. ^ "Turning off the power: Dr. Paola Marignani finds drug combination that stops growth of breast cancer cells". Dalhousie University. Retrieved 2024-05-12.
  8. ^ a b Jussinoja, Kaija. "Meet the local scientist changing the narrative for cancer". The Coast Halifax. Retrieved 2024-05-12.
  9. ^ "LKB1 Tumour Suppressor kinase". Marignani Discovery Research Laboratory. 2017-07-24. Retrieved 2024-05-12.
  10. ^ Kim, Jinhong; Xu, Zhaolin; Marignani, Paola A. (2021-10-15). "Single-cell RNA sequencing for the identification of early-stage lung cancer biomarkers from circulating blood". npj Genomic Medicine. 6 (1): 87. doi:10.1038/s41525-021-00248-y. ISSN 2056-7944. PMC 8519939. PMID 34654834.
  11. ^ Kim, Jinhong; Marignani, Paola A. (2022), Christian, Sherri L. (ed.), "Single-Cell RNA Sequencing Analysis Using Fluidigm C1 Platform for Characterization of Heterogeneous Transcriptomes", Cancer Cell Biology, vol. 2508, New York, NY: Springer US, pp. 261–278, doi:10.1007/978-1-0716-2376-3_19, ISBN 978-1-0716-2375-6, PMID 35737246, retrieved 2024-05-12
  12. ^ Marignani, Paola A.; Epand, Richard M.; Sebaldt, Rolf J. (1996-08-14). "Acyl Chain Dependence of Diacylglycerol Activation of Protein Kinase C Activity in vitro". Biochemical and Biophysical Research Communications. 225 (2): 469–473. doi:10.1006/bbrc.1996.1196. PMID 8753785.

Category:Canadian molecular biologists Category:Canadian women scientists Category:21st-century Canadian scientists Category:20th-century Canadian scientists Category:21st-century Canadian women scientists Category:20th-century Canadian women scientists Category:Academic staff of Dalhousie University

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